Consensus Conclusions On Physiological Functions Of Non-digestible Oligosaccharides in Human Health

Taking the commercial development and functional evaluation of inulin prebiotic products as an example, the development of commercial products should first determine the structure, chemical composition and daily intake of the product, and verify its safety through toxicological experiments, and confirm that it is generally recognized as safe. Food ingredients (Generally Recognized as Safe, GRAS). The FDA (Food and Drug Administration) identification of prebiotic efficacy requires dual evaluation of in vitro and in vivo experiments. The proliferation effect of inulin on various probiotics (Bifidobacterium or Lactobacillus) was verified by in vitro experiments. To qualitatively prove the mechanism or law of proliferation or metabolism, the subsequent in vivo experiments are divided into two steps: animal experiments and human experiments. The animal model was used to simulate the human intestinal environment, and the regulation effect of a certain dose of inulin on the intestinal flora of animals was studied. product. In addition, other possible physiological functions of inulin prebiotics (such as increasing mineral absorption, impact on lipid metabolism, prevention and treatment of intestinal cancer, etc.) have been verified by animal experiments, but there is still a lack of human experimental data.